Histatin-derived antimicrobial peptide platform

P113+Advanced Antimicrobial Peptide

P113+ is presented as a next-generation scientific concept based on P-113, a short antimicrobial peptide derived from human salivary Histatin-5. This page focuses on the biology of antimicrobial peptides, peptide engineering, anti-biofilm activity, and oral microbiome research.

🛡Broad-Spectrum Antimicrobial

🧬Histatin-Derived

🦠Anti-Biofilm Potential

⚖Microbiome Balance

🔬Peptide Engineering

About P-113 and P113+

P-113 is a 12-amino-acid peptide derived from the active domain of Histatin-5, a natural antimicrobial peptide found in human saliva. P113+ represents an academic and technology-facing presentation of optimized P-113 concepts, emphasizing peptide stability, antimicrobial potency, and oral microbiome research potential.

SequenceAKRHHGYKRKFH

Length12 amino acids

Approx. MW~1562 Da

OriginHuman salivary Histatin-5

Scientific Focus

Membrane-targeting antimicrobial peptide activity
Biofilm inhibition and disruption research
Antifungal activity against oral fungal species
Host-microbe interaction and microbiome modulation
Peptide sequence optimization and structure-activity relationship studies

Mechanism of Action

Pathogen Targeting

P-113 binds preferentially to negatively charged microbial membranes through electrostatic interactions.

Membrane Disruption

Peptide-membrane interaction can destabilize microbial membrane integrity and impair cell survival.

Biofilm Control

AMPs may interfere with adhesion, quorum sensing, and extracellular matrix formation.

Microbiome Balance

The research goal is to reduce harmful pathogens while supporting a balanced oral microbial ecosystem.

Antimicrobial

Designed around the AMP concept of rapid microbial membrane targeting, especially relevant to oral bacteria and mixed microbial communities.

Anti-Biofilm

Biofilm inhibition is a central research area for P-113-related peptides due to their relevance in plaque and oral microbial persistence.

Biocompatibility

Histatin-derived peptides are of interest because they are inspired by endogenous salivary defense mechanisms.

P113+ vs. P-113 Research Concept

Feature	P-113	P113+
Scientific origin	Histatin-5-derived peptide	Histatin-derived optimized peptide platform
Research focus	Antimicrobial and antifungal activity	Enhanced antimicrobial, anti-biofilm, and stability-oriented research
Application area	Oral microbiology and AMP studies	Advanced oral microbiome and peptide engineering studies
Positioning	Reference peptide	Next-generation academic and technology concept

Note: P113+ is presented here as a scientific and technology-facing designation. Specific biological performance should be supported by experimental data for each peptide sequence, formulation, and application condition.